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Immunology How does Indo1 allow measurement of signaling in real time? What is store operated calcium entry...

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Biology

Immunology

How does Indo1 allow measurement of signaling in real time? Whatis store operated calcium entry and how is it regulated?

If the EF-hand domain was mutated so it behaved like it wasalways bound to calcium how would this impact signaling?

Give 2 examples of inhibitory receptors that regulate T cellfunction How does CTLA4 reduce signaling in T cells?

Describe 3 ways that Fas/FasL interactions regulate T cellmediated immune responses

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3.6 Ratings (661 Votes)
Calcium is an important second messenger and Indo1 is a Calcium sensitive fluorophore with the excitation wavelength in the UV range So When excited the emitted fluorescence is measured which can be used in the detection of Ca2 levels in real time Storeoperated calcium entry is a ubiquitous Ca2 entry pathway that is activated upon the stimulation of plasma membrane receptors which are coupled to PIP2    See Answer
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