In a thalassemia (blood disease) prevalent in Southeast Asia,the hemoglobin A polypeptide chain is longer than normal, althoughthe mRNA length is unchanged. The normal HbA polypeptide ends withthe sequence: – Lys – Tyr – Arg –(C terminus). The mutant versionadds 30 amino acids, ending with: – Lys – Tyr – Arg – Gln – (29more amino acids) –(C terminus). The causative mutation in the HbAgene is most likely:
A. a transition mutation.
B. a transversion mutation.
C. a nonsense mutation.
D. a frameshift mutation.
E. an insertion mutation
Make sure provide the best explanation about your answer byexplaining what the question is asking first and then falsify(provide explanation) each of the choices you did not choose.Ultimately, also provide explanation for for the correct choice.Define any key concepts and terms along the way and make diagramsif necessary to provide the best explanation.
