Logo
Home Study Material Contact Search
AI Chat FREE
  1. sciences
  2. medical sciences
  3. in addition to energy needs, cancer cells also nee

In addition to energy needs, cancer cells also need metabolic intermediates for biosynthesis. Explain how increased...

50.1K

Verified Solution

Question

Medical Sciences

  1. In addition to energy needs, cancer cells also need metabolicintermediates for biosynthesis. Explain how increased reliance onglycolysis would be beneficial in this respect.
  2. Glycolysis offers a growth advantage to cancers growing underhypoxic conditions. Why might this be the case? (Hint: what is theproduct of anaerobic glycolysis?)
  3. A decrease in oxidative phosphorylation also leads to adecrease in reactive oxygen species (ROS). Why might this be anadvantage for cancer cells?

Answer & Explanation Solved by verified expert
3.8 Ratings (516 Votes)
1 Tumor cells live in an hypoxic or low oxygen environment Hence they undergo anaerobic respiration to obtain ATP In anaerobic pyruvate obtained by glycolysis is converted to lactic acid and NAD is regenerated from NADH This NAD is used again as reducing power for glycolysis This NAD will help increase glycolysis Tumor cells are also capable of aerobic respiration where ATP is generated by TCA cycle coupled to oxidative phosphorylation PFK1 is an important regulator of glycolytic flux In cancer cells PFK2 is expressed in high amounts which leads to production of Fructose 26 bisphosphate This F26 bP overcome negative feedback regulation of PFK21 by ATP Thus glycolysis can occur even in high ATP levels Pyruvate kinase M2 is expressed in cancer cells over PKM1 isoform which converts PEP to Pyruvate In    See Answer
Get Answers to Unlimited Questions

Join us to gain access to millions of questions and expert answers. Enjoy exclusive benefits tailored just for you!

Membership Benefits:
  • Unlimited Question Access with detailed Answers
  • Zin AI - 3 Million Words
  • 10 Dall-E 3 Images
  • 20 Plot Generations
  • Conversation with Dialogue Memory
  • No Ads, Ever!
  • Access to Our Best AI Platform: Zin AI - Your personal assistant for all your inquiries!
Become a Member

Other questions asked by students

Q

Solo Corp. is evaluating a project with the following cash flows: Year Cash Flow 0 –$ 47,000 1 16,900 2 20,300 3 25,800 4 19,600 5 – 9,500 The company uses a discount...

Finance
Q

Refute the argument that membranes resemble an inert plastic bag.

Biology
Q

1) The data below apply to the formation of urea (NH2CONH2) from ammonium cyanate (NH4CNO). Initially,...

Chemistry
Q

Look at the diagram and evaluate Which of the statements below is TRUE I J...

Geometry
Q

1 Find the limit when h 0 of the function sin h h What is...

Basic Math
Q

What is the critical value t for a 99 confidence interval when n 20 Select...

Statistics
Q

The annual amounts of rainfall in a certain region are modeled usi The mean of...

Statistics
Q

A company that has 150 employees chooses a committee of 17 to represent employee retirement...

Statistics
Q

Complete parts a d for the functions f x x 6 and g

Calculus
Q

Filght Cate prepares in-ilight meals for alrines and its planning budget for July appears below:...

Accounting
Q

Determine el ndice de margen de seguridad a partir de los siguientes datos: Ventas $30...

Accounting
Q

You bought 60 shares of a mutual fund one year ago for $50 per share....

Finance