In animal tissue, the rate of conversion of pyruvate ofacetyl-CoA is regulated by the ratio of active, phosphorylatedpyruvate dehydrogenase to inactive, unphosphorylated pyruvatedehydrogenase (PDG) complex. Explain the impact of the followingregulators on the activity of pyruvate dehydrogenase complex inanimal tissue extracts when treated with:
- high concentrations of acetyl-CoA
