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In autoimmune diseases, part of your immune system works against your own body.In Rheumatoid arthritis, this...

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Biology

In autoimmune diseases, part of your immune system works againstyour own body.In Rheumatoid arthritis, this leads to inflammationof joints due to infiltration of immune cells. How do TNF-α andIL-1 enhance the infiltration of leukocytes into the jointspace?

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Rheumatic arthritis is an immune mediated inflammatory diseaseThe synovial layer is normally 13 cells thick In rheumatic arthritis this lining is greatly hypertrophied 810 cells thick Primary cell populations in this layer are fibroblasts and macrophagesIn RA the subintimal area of synovial joint is heavily infiltrated with inflammatory cells including T and B lymphocytes macrophages mast cells and mononuclear cells that differentiate into    See Answer
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