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In July 2000, the Protein Data Bank named the nucleosome “molecule of the month.” In an...

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Biology

In July 2000, the Protein Data Bank named the nucleosome“molecule of the month.” In an accompanying report, David Goodsellwrote that

\"The job of the nucleosome is paradoxical, requiring it toperform two oppo- site functions simultaneously. On one hand,nucleosomes must be stable, forming tight, sheltering structuresthat compact the DNA and keep it from harm. On the other hand,nucleosomes must be labile enough to allow the information in theDNA to be used. Polymerases must be allowed access to the DNA, bothto transcribe messenger RNA for building new proteins and toreplicate the DNA when the cell divides.\"

Explain how nucleosomes help DNA to adopt a highly-compactstructure while also keeping the DNA molecule accessible fortranscription and replication?

Answer & Explanation Solved by verified expert
3.6 Ratings (373 Votes)
in eukaryotes the nucleosome is the basic structural unit of DNA packaging The structure of a nucleosome consists of a segment of DNA wound around eight histone proteins and resembles thread wrapped around a spool The nucleosome is the fundamental subunit of chromatin Each nucleosome is composed of a little less than two turns of DNA wrapped around a set of eight proteins called histones which are known as a histone octamer Each histone    See Answer
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