In the glycolytic pathway, the enzyme triose phosphate isomerasecatalyzes the conversion of of dihydroxyacetone phosphate toglyceraldehyde-3-phosphate, which is then immediately utilized byglyceraldehyde-3-phosphate hydrogenase to continue throughglycolysis. In an experimental cell culture model, inhibition oftriose phosphate isomerase leads to cell death in anaerobicconditions. These cells survive, however under aerobic conditions.Please explain these findings. In your answer consider the energyproduction in aerobic vs. anaerobic metabolism.
