Long-term Potentiation (LTP) and Long-term Depression
(LTD). Please discuss these two forms of synaptic plasticity that
can...
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Long-term Potentiation (LTP) and Long-term Depression(LTD). Please discuss these two forms of synaptic plasticity thatcan be studied in research and represent molecular and cellularevents underlying activity-dependent synaptic plasticity. What areLTP and LTD? What chain or cascade of events takes place that leadto LTP AND LTD? Specifically now address Early vs. Late LTP andeffects of cAMP and PKA...
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LTPit is the process by which the synaptic connection between theneurons become stronger with frequent activationLTP is thought tobe a way in which the brain changes in response to experience andthus maybe e mechanism underlying learning and memoryThere are a number of ways in which LTP can occur The bestknownmechanism involves a glutamate receptor known as NMDA receptor inNMDA receptor dependent LTP glutamate release first activates asubtype of glutamate receptor known as the AMPA receptorNMDAreceptors are found nearby these AMPA receptors but are notactivated by low levels of glutamate release because the Ionchannels of an NMDA receptor is blocked by a magnesium ion Iffrequent action potentials cause greater stimulation of AMPAreceptors however this will cause the postsynaptic neuron todepolarize which eventually causes the voltagedependent magnesiumblockage of the NMDA receptor to be removed allowing
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