Methanol and ethanol are both oxidized by alcohol dehydrogenase(ADH). Methanol is poisonous because it is oxidized by ADH to formthe highly toxic compound formaldehyde. The adult body has 40 L ofwater, throughout which these alcohols are rapidly and uniformlydistributed. The densities of both alcohols are 0.79 g/mL. The Kmof ADH for ethanol is 1.0x10-Ââ€3 M, and for methanol the Km is1.0x10-Ââ€2 M. The molecular mass of methanol is 32 g/mol and thatof ethanol is 46 g/mol. If an individual consumed 100 mL ofmethanol (a leathal amount), how much 100-Ââ€proof whiskey (50%ethanol by volume) must this person consume in order to reduce theactivity of ADH toward methanol to 5%? Assume the Ki for ethanol =Km.
