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Modes of action of antibacterial drugs 1 Inhibition of cell wall synthesis Examples penicillin bacitracin...

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Modes of action of antibacterial drugs 1 Inhibition of cell wall synthesis Examples penicillin bacitracin cephalosporin vancomycin 4 Inhibition of nucleic acid synthesis Examples rifamycin transcription quinolones DNA replication metronidazole 5 Action as antimetabolites Examples sulfonilamide trimethoprim Figure 13 2 Microbiology 6 e 2005 John Wiley Sons Bacterial cell wall DNA replication 2000 DNA ooooo PABA 2 Disruption of cell membrane function Example polymyxin Transcription Translation mRNA Bacterial cell membrane 3 Inhibition of protein synthesis Examples tetracycline erythromycin streptomycin chloramphenicol In general which of these modes of action would yield drugs with the highest therapeutic indices Which of these modes of action does not depend on active microbial growth

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