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Muscular Dystrophy (BMD), and an individual with Duchene’s Muscular Dystrophy (DMD). DNA Sequence (1141-1200 bp) WT#1 cagaatgaa gcagagcca gagtttgct...

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Biology

Muscular Dystrophy (BMD), and an individual with Duchene’sMuscular Dystrophy (DMD).

DNA Sequence (1141-1200 bp)

WT#1

cagaatgaa gcagagcca gagtttgct tcgagactt gacacggaa ctcaaagaacttaac

WT#2

aagaatgaa gctgagcca gagttcgct tcgagactt gacacagaa ctgaaagaacttaac

WT#3

aagaatgaa gcagagcca gagtttgct tcgagaatt gagacagaa ctcaaagaacttaac

BMD

aagaatgaa gctgagcca gagtttgct tcgagactt gagacagaa ctcaaagaacttaac

DMD

aagaacgaa gcagagcca gagattgct tagagaatt gacacggaa ctcaaagaacttaac

DNA Sequence (1201-1260bp)

WT#1

actcagtgg gatcacatg tgccaacag gtatagaca atctctttc actgtcgctagcctc

WT#2

acgcagtgg gatcatatg tgccaacag gtatagaca atctccttc actgtggctagcctc

WT#3

acgcagtgg gatcacatg tgccaacag gtatagaca atctccttc actgtcgcttgcttc

BMD

accagtggg accacatgt gccaacagg tatagacaa tctctttca ctgtggcttgcttca

DMD

actcagtgg gaccatatg tgccaacag gtatagaca atctctttc actgtggctagcctc

6.What type(s) of mutations are there between the BMDstrand and the WT strands. What effects, if any, do you think thesemutations have on the function of the dystrophin protein. Explainyour reasoning. (Assume that the observed mutations ONLY affect thepolypeptide sequence in this exon.)

Answer & Explanation Solved by verified expert
4.1 Ratings (659 Votes)
The DNA sequences were subjected to ClustalW alignment Theresults are as followsThe site marked with 1 indicates a deletion of nucleotideThis deletion leads to frameshift mutation ie    See Answer
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