Name the three pathways of complement activation, and describe
similarities, differences and major outcomes.
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Biology
Name the three pathways of complement activation, and describesimilarities, differences and major outcomes.
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ComplementComplements are a group of proteins normally found in serum inan inactive form but when activated they augment the immuneresponsesIt constitutes about 5 of normal serum proteinsThey are antigen nonspecific Their level does not increasefollowing either infection or vaccinationIt is species nonspecificIt is heatlabile 56C for 30 minutesIt binds to the Fc region of antibody IgMThe site of synthesis of Complements mainly by the liver alsoin GIT macrophage and spleenComplement PathwaysThere are three pathways of complement activation1 Classical pathway This is an Ab dependent pathway triggered bythe AgAb complex2 Alternative
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