Osteogenesis imperfecta is a disease caused by a mutation incollagen (type X), which causes the infected individual to havebrittle bones that easily fracture. Collagen typically has a triplehelical structure consisting of three intertwined polypeptidechains (as shown below) with each polypeptide chain having aglycine every third amino acid.
While Osteogenesis imperfecta can be caused by a variety ofmutations, a single amino acid change is sufficient to causecertain forms of the disease. If the mutation resulted in theglycine being changed to another amino acid, which amino acid doyou think would be most likely be responsible for this disease? Ina sentence, explain your choice.
Write down both the tRNA and coding DNA sequence for the aminoacid found in the wild-type protein. Make sure to label the 5’ and3’ ends.
Where in the cell would collagen be produced? Briefly explainwhy.
