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Part 1 The circuit model for the resting state of the axon has been introduced in class. Use this circuit to do the following: 1. Look up inside and outside concentrations for sodium ions and calculate the equilibrium potential for sodium. Use this value for one of the batteries in the circuit model. 2. Look up inside and outside concentrations for potassium ions and calculate the equilibrium potential for potassium. Use this value for one of the batteries in the circuit model. 3. Look up the resting potential for a human axon. 4. Choose values of the resistances in the circuit model that represents the membrane ability to limit the flow of sodium and potassium ions. Calculate the resisting potential of the circuit model using these values of resistances. If the resting potential of the circuit model does not agree with the actual resting potential, adjust the resistances until you get agreement Part II One way that a circuit model is useful is that we can use the circuit model to predict results of certain situations, without having to do experiments on real cells. Use your circuit model to predict how the resting potential changes under one of the following: a) A person is dehydrated so that the outside concentrations of all the ions are increased by 20%. b) A toxin is introduced that causes the cell membrane to be less permeable to potassium ions by 50%, while keeping the permeability to sodium ions the same. c) A person takes a low salt diet to the extreme so that both the inside and outside concentrations of sodium are reduced by 25%, while keeping the concentrations of potassium ions the same. For the situation that you choose, discuss qualitatively whether the effect on the resting potential makes sense. You should say something like the resting potential (increased/decreased) and this makes sense because ..." Go into explicit details on your qualitative reasoning, based on physics and biology principles and definitions. Part 1 The circuit model for the resting state of the axon has been introduced in class. Use this circuit to do the following: 1. Look up inside and outside concentrations for sodium ions and calculate the equilibrium potential for sodium. Use this value for one of the batteries in the circuit model. 2. Look up inside and outside concentrations for potassium ions and calculate the equilibrium potential for potassium. Use this value for one of the batteries in the circuit model. 3. Look up the resting potential for a human axon. 4. Choose values of the resistances in the circuit model that represents the membrane ability to limit the flow of sodium and potassium ions. Calculate the resisting potential of the circuit model using these values of resistances. If the resting potential of the circuit model does not agree with the actual resting potential, adjust the resistances until you get agreement Part II One way that a circuit model is useful is that we can use the circuit model to predict results of certain situations, without having to do experiments on real cells. Use your circuit model to predict how the resting potential changes under one of the following: a) A person is dehydrated so that the outside concentrations of all the ions are increased by 20%. b) A toxin is introduced that causes the cell membrane to be less permeable to potassium ions by 50%, while keeping the permeability to sodium ions the same. c) A person takes a low salt diet to the extreme so that both the inside and outside concentrations of sodium are reduced by 25%, while keeping the concentrations of potassium ions the same. For the situation that you choose, discuss qualitatively whether the effect on the resting potential makes sense. You should say something like the resting potential (increased/decreased) and this makes sense because ..." Go into explicit details on your qualitative reasoning, based on physics and biology principles and definitions

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