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Provide a detailed description of the detrimental effects and mechanism of action of a known endocrine...

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Medical Sciences

Provide a detailed description of the detrimental effects andmechanism of action of a known endocrine disruptor.

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Endocrine disruptor Endocrine disruptors are known to cause harmful effects to human through various exposure routes These chemicals mainly appear to interfere with the endocrine or hormone systems As importantly numerous studies have demonstrated that the accumulation of endocrine disruptors can induce fatal disorders including obesity and cancer Using diverse biological tools the potential molecular mechanisms related with these diseases by exposure of endocrine disruptors Recently pathway analysis a bioinformatics tool is being widely used to predict the potential mechanism or biological network of certain chemicals In this review we initially summarize the major molecular mechanisms involved in the induction of the above mentioned diseases by endocrine disruptors Additionally we provide the potential markers and signaling mechanisms discovered via pathway analysis under exposure to representative endocrine disruptors bisphenol diethylhexylphthalate and nonylphenol The review emphasizes the importance of pathway analysis using bioinformatics to finding the specific mechanisms of toxic chemicals including endocrine disruptors MOLECULAR MECHANISMS WITH ENDOCRINE DISRUPTORS In general endocrine disruptors are thought to affect an organisms endocrine system Additionally endocrine disruptors are known to    See Answer
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