Q2. Discuss all three of the following
topics;
a. beige (aka brite) fat
b. AMP-activated protein kinase (AMPK)
c....
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Medical Sciences
Q2. Discuss all three of the followingtopics;
a. beige (aka brite) fat
b. AMP-activated protein kinase (AMPK)
c. basal metabolic rate (BMI)
Please give a detailed answer. Add supportive equations or flowdiagrams if possible.
Thank you.
Answer & Explanation
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Adult humans have UCP1expressing thermogenic adipocytes knownas beigebriteadipocytes interspersed in WAT Chronic exposure to cold oradrenergic agonistsincreases the recruitment of brown adipocytes promotingaccretion of BAT mass The samestimuli also promote the recruitment of brownlike beigebriteadipocytes in WAT depots aphenomenon known as WAT browning Both brown and beige cellshave thermogenicfeatures sharing morphological and molecular characteristicssuch as multilocularity andexpression of thermogenic genes suggesting their contribution toenergy dissipationHowever beige and brown fat cells exhibit distinct geneticsignatures that reflect theirdifferent lineage originsAdult humans have UCP1expressingthermogenic adipocytes known as beigebriteadipocytes interspersed in WAT Chronic exposure to cold oradrenergic agonistsincreases the recruitment of brown adipocytes promotingaccretion of BAT mass The samestimuli also promote the recruitment of brownlike beigebriteadipocytes in WAT depots aphenomenon known as WAT browning Both brown and beige cellshave thermogenicfeatures sharing morphological and molecular characteristicssuch as multilocularity andexpression of thermogenic genes suggesting their contribution toenergy dissipationHowever beige and brown fat cells exhibit distinct geneticsignatures that
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