Question 156
Which of the following is not among the 4 most commonly mutatedgenes in pancreatic cancer?
- KRAS
- p16 gene
- TGFb eta
- SMAD4
Question 164
Pancreatic Ductal Adenocarcinoma (PDAC) tumors typically arisefrom (choose all that apply):
- tumorigenic pancreatic stellate cells
- neoplasms derived from ductal cells
- neuroendocrine cells
- grade 3 intraepithelial neoplasms
Question 170
A drug that inhibits the interaction between PD and PDL-1 wouldbe classified as a(n)
- NSAID
- checkpoint inhibitor
- adoptive cell transfer inhibitor
- cytokine-mediated chemotherapeutic agent
Question 60
Chronic inflammation has been observed to play a role inpromoting which of the following?
- tumor cell proliferation
- tumor cell genetic mutations
- angiogenesis
- metastasis
- All of the above.
Question 73
Which of the following is not a common symptom of pancreaticcancer?
- lower back pain
- jaundice
- bloody stools
- diabetes
- obstructed bile duct
Question 82
CD8+ and CD4+ activation can be inhibited when ______________ ontumor cells cause:
- MHC receptors ; a downregulation of Programmed Death (PD)ligand expression on T cell membranes
- Programmed death ligand (PDL-1) molecules ; a downregulation ofAkt/PI3K-mediated growth/proliferation
- T cell ; the activation of NK cells
- None of the above.
