Question 16 In people with Grave’s disease, the immunesystem produces a large amount of a protein that is so much likeTSH (Thyroid stimulating hormone) that it binds to cells of thethyroid gland and acts like TSH. Unlike TSH, the secretion of thisprotein does not respond to negative feedback.
a) What effect will this abnormal protein have on the functionof the thyroid gland?
b) What effect will this abnormal protein have on the release onhormones from the hypothalamus and anterior pituitary gland?
c) If TSH binds to membrane-bound receptors on cells of thethyroid gland will a second messenger system be needed for hormonalaction? Explain.
