Question 3 You are doing genetic studies on a family that hasseveral members with a particular disease. You identify a gene witha one base pair difference (C→T) between the patients (T) and ahealthy relative (C). This gene encodes a protein that acts as anenzyme in cellular metabolism.
(A) Describe two ways in which a C→T mutation in the DNA couldcause a loss-of-function disruption in a protein.
(B) Describe how it is possible that a loss-of-function mutationcan be dominant to wild-type
(C) Describe three potential consequences of a loss-of-functionmutation in the protein described in (A). (Answer could be at acellular or organismal level.)
(D) Describe two ways in which a C→T mutation in the DNA couldcause a gain-of-functiondisruption in a protein.
