Question: How does poliovirus replicate in the epithelial cell
of intestine? Describe in detail, not only...
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Biology
Question: How does poliovirus replicate in the epithelial cellof intestine? Describe in detail, not only main idea.
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Poliovirus is a small nonenveloped icosahedral virus of about 30 nm in diameter It possesses a 75 kb ssRNA genome that is infectious translated immediately upon entry into the cell The genome contains a 5nontranslated region NTR that contains an internal ribosome entry site IRES followed by a single open reading frame encoding a polyprotein that is cleaved sequentially into intermediate precursors and 11 mature poliovirus proteins The genome is also polyadenylated at the 3NTR A viral protein known as VPg virion protein genomelinkedassociates with the 5end of the genome and is thought to act as a protein primer for replication of the genome 1 Attachment Penetration and Uncoating The poliovirus capsid is composed of 60 copies each of 4 repeating proteinsVP1 VP2 VP3 and VP4 VP2 and VP4 are derived from autocatalysis of VP0 during maturation of the virion VP1 VP2 and VP3 form the surface of the capsid with VP4 associating on the inner capsid wall VP1 forms a starshaped plateau or mesa on the fivefold axis which is surrounded by a deep canyon into which the cell surface receptor binds The poliovirus virion is acid resistant which allows it to survive the low pH of the stomach to initiate
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