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Receptor binding motifs such as RGD have highly selective recognition for cell adhesion. Outline a strategy...

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Biology

Receptor binding motifs such as RGD have highly selectiverecognition for cell adhesion. Outline a strategy for incorporatinga cell adhesion. Outline a strategy for incorporating a celladhesion recognition domain to a biomaterial. Address the problemssurrounding domain quantity, type and affinity in yourdiscussion.

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RGD is a tri amino acid peptide made up of ArginineGlycineAspartate It is most commonly used adhesive peptide which is much effective in attaching various cell tyoes to plethora of biomaterials Extracellular matrix proteins such as integrins osteopontin fibrinogen fibronectin bone sialoproteina nd vibronectin alongwith collagens and laminins contains a prime binding domain that is RGD Thus the artificial peptide RGD can bind to many integrin species Due to this recognition benefit the artificial RGD maintains its functionality during the sterilization and processing steos of biomaterial synthesis Again this property nominalises the immne    See Answer
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