Samuel is a 34-year-old man. He is seeing his family doctor
today because he has been...
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Samuel is a 34-year-old man. He is seeing his family doctortoday because he has been feeling more and more muscle strainlately.
After several investigations, a diagnosis is made: primaryhypoparathyroidism, which means that its parathyroid glands do notsecrete enough PTH.
a) Explain what effect this pathology would have on Samuel'scalcemia. Produce a clear, precise and detailed answer bydescribing all the functions and effects of PTH.
b) This disorder of calcemia causes an inhibition of neuronswhich explains muscle weakness. What link do you make betweencalcemia and the functioning of neurons? In your answer, you mustexplain the precise and detailed functioning of a chemicalsynapse.
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a Parathyroid hormone is secreted by the parathyroid gland that is present near the thyroid gland It is secreted in response to low calcium levels in blood via exocytosis from membrane bound vesicles It has a short halflife and it removed by kidneys and liver Hypoparathyroidism is the less production of PTH by the parathyroid glands PTH and Calcemia Calcemia or low calcium levels in blood activate secretion of PTH It stimulates the release of calcium by the osteoclasts Osteoclasts are bone cells that degrade bone Bone matrix has calcium in
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