Scenario 1. Â
A recent research publication connected migraine headachefrequency with a single nucleotide polymorphism.  Theaffected gene encodes the TRPM8 channel protein that transportsions across a membrane.  Interestingly, this geneticvariation may have become common in northern European populationsbecause it also grants them a higher tolerance to coldtemperatures
1.  Sequencing of the TRPM8 gene and thesurrounding region of the chromosome has been completed.
- Describe how you know where transcription of this gene wouldstart.
- Describe how you know where translation of this gene wouldstart.
2.  Using the TRPM8 gene/protein as anexample, indicate where you would find this type of bond, what theyare made from, and describe how they are formed.
a)Â Â phosphodiester bonds
b)Â Â peptide bonds
3.  A new TRPM8 mutation has been identified in afamily in Indiana.  This protein has a missense mutationin the sequence that results in a mutation labelled T118S.
a)Â Â What does this mutation notation indicate?
b)Â Â Using the genetic code, dictate the RNA sequencefor this region.
c)Â Â What is the DNA sequence of the template strandfor this region?
