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Sterility is associated with loss of function (LOF) at a gene Z. The gene has 5000...

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Biology

Sterility is associated with loss of function (LOF) at a gene Z.The gene has 5000 bases where LOF mutations can occur. Assuming thehuman mutation rate is 2x10^-8 per generation. Homozygotes for LOFalleles at Z are sterile, and heterozygotes have mild sterilityissues. The heterozygotes for LOF alleles at Z have 20% fewerchildren than an average individual I the population, but suffer noother ill effects. A) What is the frequency of the Z allele undermutation-selection balance? B) What proportion of the individualsin the population are sterile due to being homozygous for a LOFmutation at Z?

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3.6 Ratings (316 Votes)
Loss of function Mutation It is also called inactivated mutations result in the gene product having less or no function Here the gene Z Has 5000 bases where lof mutations can occur The human mutation rate is 2 X 108 per generation Homozygotes for LOF alleles at Z are sterile    See Answer
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