Tetrodotoxin and lidocaine are both drugs that cause local
analgesia or numbness where applied to the...
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Biology
Tetrodotoxin and lidocaine are both drugs that cause localanalgesia or numbness where applied to the skin.  Explainthis outcome, with reference to the effects on membrane potentials,ion flux and overall neuronal activity. Would you predict thatthese drugs could affect other neurons than just those mediatingcutaneous sensation? If so, how? If not, why not?
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Tetrodotoxin In normal neurons there is high concentrations of K ions and low concentrations of Na ions in axon Hence axons have negative potential When axons are stimulated by impulses there is flow of Na into the cell via sodium channels resulting in positive membrane potential This results in membrane depolarization When the depolarization reaches a threshold value action potential results This stimulates neuronal activity Tetrodotoxin is the poison produced
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