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The development of neoplasia involves a complex pathogenesis with mutations in a number of genes contributing. 1...

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Biology

The development of neoplasia involves a complex pathogenesiswith mutations in a number of genes contributing.

1 Compare and contrast the two major categories of genesinvolved in the development of neoplasia.

2. Name 3 examples from each of the two majorcategories of genes you discussed above (6 examples total).Describe the normal function of these genes and how dysregulationof each of these genes contributes to the development ofneoplasia.

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1 Neoplasia means new growth and is the term used to define uncontrolled and rapid growth of cells It is most commonly seen in different types of cancer A neoplastic cell will have mutations in its genes which allows it to grow uninhibited by the cells regulatory mechanisms The mutations can be in different types of genes The 2 most common type of genes which are mutated in a neoplastic cell are tumor suppressor genes and protooncogenes Tumor suppressor genes The proteins encoded by tumor suppressor genes are involved in inhibiting cell proliferation andor inducing cell apoptosis Mutations in these genes leads to inactivation of the proteins encoded by them Such mutations are known as loss of function mutations This often leads to neoplasia because the    See Answer
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