The following data are simulated for a 200 mg dose of a druggiven p.o. and i.v. VD = 500L Rate of absorption (oral only) =0.0096 min-1 (IV bolus was assumed 100% absorption immediately)Rate of elimination = ke = 0.0099 min-1 Therefore, eliminationhalf-life (t1/2) = 0.693/ke = 70 min Calculate the AUC of both p.o.and i.v. doses. I suggest using the trapezoidal method forcalculating AUC: sum of [{avg of two points}*{time between twopoints}]. Then calculate the bioavailable fraction (F).
Time (min) | Cp (ug/L) |
1 | 3.78 |
5 | 17.8 |
10 | 33.2 |
15 | 46.2 |
30 | 74.4 |
45 | 89.9 |
60 | 96.7 |
90 | 94.9 |
120 | 83.4 |
180 | 55.4 |
240 | 33.5 |
360 | 11.0 |
420 | 6.14 |
540 | 1.90 |
Time (min) | Cp (ug/L) |
1 | 396 |
5 | 381 |
10 | 362 |
15 | 345 |
30 | 297 |
45 | 256 |
60 | 221 |
90 | 164 |
120 | 122 |
180 | 67.3 |
240 | 37.2 |
360 | 11.3 |
420 | 6.26 |
540 | 1.91 |
