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  3. the following data are simulated for a 200 mg dose

The following data are simulated for a 200 mg dose of a drug given p.o. and...

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Biology

The following data are simulated for a 200 mg dose of a druggiven p.o. and i.v. VD = 500L Rate of absorption (oral only) =0.0096 min-1 (IV bolus was assumed 100% absorption immediately)Rate of elimination = ke = 0.0099 min-1 Therefore, eliminationhalf-life (t1/2) = 0.693/ke = 70 min Calculate the AUC of both p.o.and i.v. doses. I suggest using the trapezoidal method forcalculating AUC: sum of [{avg of two points}*{time between twopoints}]. Then calculate the bioavailable fraction (F).

Time (min)

Cp (ug/L)

1

3.78

5

17.8

10

33.2

15

46.2

30

74.4

45

89.9

60

96.7

90

94.9

120

83.4

180

55.4

240

33.5

360

11.0

420

6.14

540

1.90

Time (min)

Cp (ug/L)

1

396

5

381

10

362

15

345

30

297

45

256

60

221

90

164

120

122

180

67.3

240

37.2

360

11.3

420

6.26

540

1.91

Answer & Explanation Solved by verified expert
3.7 Ratings (632 Votes)
For OPSTEP 1 Plot Average concentration Cp versus timeSTEP 2 Calculate Area under the curve using the formulaAUCn cn cn12 x TimeintervalFor POTime minPO CpAvg    See Answer
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