The genetic term “loss of function†is used to describe anymutation in the DNA that leads to a particular protein that cannotfunction. There are many reasons why a protein may not befunctioning any longer…digging into your knowledge on the mechanismof gene expression and gene expression regulation, describe amutation that could lead to a loss of function mutation. Where isthe mutation in the gene? What function of gene expression or geneexpression regulation is it affecting? How is it leading to a lossof function for the protein encoded for within that gene?
But I’m going to restrict your answer…describe a mechanism thatDOES NOT include a point mutation leading to missense, nonsense, orframeshift – in other words, choose a mutation/mechanism other thana mutation that leads to a change in the protein-coding region of amature mRNA. I want you to think outside of that particularbox.
