The importance of the translational molecular machinery toinsert the correct amino acid into the primary structure of apolypeptide is of paramount importance to ensure the fidelity ofthe code. Part of the reason why this process is so accurate is dueto the action of tRNA amino-acyl synthetase (ARSs) enzymes.Mutations within the genes for ARSs, are known to cause certainhuman maladies, such as the neurodegenerative disorderCharcot-Marie-Tooth (CMT) disease along with other central nervoussystem dysfunctions, and cancer. Interestingly, not all those whopossess mutations within specific ARS genes do not display thedisease phenotype. Provide at least one reason why a person mightsurvive. Remember, do not just name a concept. Describe the conceptand then explain WHY (on a molecular level) this explanation holdstrue.
