The isoleucyl tRNA synthetase has a proofreading function that ensures the fidelity of the aminoacylation...
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The isoleucyl tRNA synthetase has a proofreading function that ensures the fidelity of the aminoacylation reaction Why does the histidyl tRNA synthetase lack such a proofreading function O O O A ribosomal polymerase proofreads the final protein so there is no need for all of the tRNA synthetases to have a proofreading function An elongation factor EF Tu ensures correct tRNA codon association Histidine is a structurally distinct amino acid whereas isoleucine is similar to leucine and valine Histidine is a class I tRNA synthetase so aminoacyl AMP directly binds to the 2 OH group eliminating the need for proofreading
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