The mortality experience of 8146 male employees of a research,engineering, and metal-fabrication plant in Tonawa- nda, New York,was studied from 1946 to 1981 [2]. Potential workplace exposuresincluded welding fumes, cutting oils, asbestos, organic solvents,and environmental ionizing ra- diation, as a result of wastedisposal during the Manhattan Project of World War II. Comparisonswere made for specific causes of death between mortality rates inworkers and U.S. white-male mortality rates from 1950 to 1978.
Suppose that 17 deaths from cirrhosis of the liver were observedamong workers who were hired prior to 1946 and who had worked inthe plant for 10 or more years, whereas 6.3 were expected based onU.S. white-male mortality rates.
7.48 What is the SMR for this group?
7.49 Perform a significance test to assess whether there is anassociation between long duration of employment and mortality fromcirrhosis of the liver in the group hired prior to 1946. Report ap-value.
