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The “reading frame hypothesis” can explain the difference in phenotype between Duchenne and Becker muscular dystrophies (DMD and BMD...

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Biology

The “reading frame hypothesis” can explain thedifference in
phenotype between Duchenne and Becker muscular dystrophies(DMD
and BMD respectively), diseases which are both caused bymutations
affecting the gene encoding the protein dystrophin. How hasour
understanding of the molecular bases of these two diseases ledto
development of molecular therapies for DMD using antisense
oligonucleotides to modulate dystrophin RNA splicing, and involvinga
mechanism of so-called exon skipping? (min 500words)

Answer & Explanation Solved by verified expert
4.0 Ratings (581 Votes)
the mechanism of exon skipping occurs when there are non sense or missense mutations taking place in the BRCA1 genes or other genes In this process there will be skipping of Exxons which may be one or more and this process takes place in the nucleus This is also referred to as NAS or nonsense mediated altered splicing In the genetic therapies    See Answer
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