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Think of a toy model of a dimeric receptor binding with a divalent ligand. The KDs...

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Biology

Think of a toy model of a dimeric receptor binding with adivalent ligand. The KDs for binding between a two-armedcompound LL1 (this is the ligand) and individualreceptors R1 and R2 are:

R1 … 7.9nM            R2 … 50.1 nM

Now think of a protein R1-R2, which is aprotein comprised of both R1 and R2. At a temperature 300K, ifthere is no loss of energy/entropy to induce conformational changesof the protein and ligand during the binding, what is the expectedKD between LL1 and R1-R2 and corresponding deltaG?

Answer & Explanation Solved by verified expert
4.0 Ratings (495 Votes)
equilibria among monomeric proteins and a bivalent ligand equilibrium between a monovalent ligand l a monomeric protein p and a complicated of protein and ligand p l this equilibrium is characterised via the dissociation regular kd in which KdLPPL p    See Answer
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