Think of a toy model of a dimeric receptor binding with adivalent ligand. The KDs for binding between a two-armedcompound LL1 (this is the ligand) and individualreceptors R1 and R2 are:
R1 … 7.9nM            R2 … 50.1 nM
Now think of a protein R1-R2, which is aprotein comprised of both R1 and R2. At a temperature 300K, ifthere is no loss of energy/entropy to induce conformational changesof the protein and ligand during the binding, what is the expectedKD between LL1 and R1-R2 and corresponding deltaG?
