To maintain a stable weight, there must be energy balance.Energy intake is equal to energy expenditure. However, when thisenergy balance is disrupted it can lead to individuals who areunderweight or overweight. Maintaining proper energy balanceinvolves complex interactions among several organ systems in thebody. In the hypothalamus there is a satiety center and a hungercenter. Leptin is an anorexigenic (i.e., satiety) signal, whereasghrelin is an orexigenic signal (i.e., promotes appetite). Leptinis a peptide hormone produced by adipocytes. Ghrelin is a peptidehormone produced by gastric cells in the stomach. There are leptinreceptors and ghrelin receptors in the hypothalamus.
Question: From its point of origin, trace how a molecule ofghrelin will move through the circulatory system (including throughthe heart) and ultimately bind to a receptor in the hypothalamus(nervous tissue).
