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Transcription of the mammalian Cytochrome P450 1A1 gene is induced by xenobiotics such as dioxin. The mechanism...

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Biology

Transcription of themammalian Cytochrome P450 1A1 gene is induced byxenobiotics such as dioxin. The mechanism of induction illustratesmany steps which are typical of signal-regulated transcriptionfactors. （16 marks）

  1. Describe in detail the steps involved in dioxin induction ofthis gene
  2. Outline an in vitro experiment you could carry out toshow that Arnt is essential for the dioxin receptor to bind to theresponse element of the Cytochrome P450 1A1 gene.

no more detail！Thx

Answer & Explanation Solved by verified expert
4.3 Ratings (1033 Votes)
AnswerHereare the following steps involved in the Cytochrome P450 1A1 geneinduction by dioxinFirstly cell cultureis prepared For that we can use the mouse hepatoma cell line    See Answer
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