Ubiquitination relies on 3 enzymes E1, which activate ubiquitin;E2, which are the conjugating enzymes, and E3 enzymes, which helpguide the E2 enzymes to specific substrates. In any given cellthere are just a couple types of E1 enzymes, several types of E2enzymes that partner with small subsets of E3 enzymes, and evenmore types of E3 enzymes, which bind with small subsets of specificprotein substrates. Given this information, which of thesemutations would you hypothesize to be the mostharmful to a cell?\"
| a. | a mutation in one type of E1 enzyme |
| b. | a mutation in one type of E2 enzyme |
| c. | a mutation in one type of E3 enzyme |
| d. | all of these mutations would be equally harmful |
