What happens with blockage of fast sodium channels? Am I correct
to say that it increases...
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What happens with blockage of fast sodium channels? Am I correctto say that it increases refractory period as phase 0 of fast AP isdelayed? Does this mean a decrease in heart rate due to decrease inrate of contractility from decreased spread of depolarization?
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The blockade of fast sodium
channels results in suppression/ depression of phse 0
depolarization whereby Vmax declines.
This results in prolongation of
duration of action potential by decreasing conduction.
There is a decrease in the
conductivity and increased refractoriness.
The cells are unable to undergo
depolarization (due to blockade of sodium channels) and retard the
generation of action potential.
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