What two types of bio molecules (of the four major classes) show
oxidative damage when exposed...
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Biology
What two types of bio molecules (of the four major classes) showoxidative damage when exposed to the combination of metformin anddichloroacetate when treating breast cancer cells?
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Lipid and proteins are two class of biomolecules are get damageddue to oxidative stress Oxidative stress is critical to theetiology of many oxidative stress related diseases especiallyneurodegenerative diseases and cancers Inflammation induces ROSand RNS production via respiratory bursts and inflammatorycytokines which can activate many oxidant generating enzymes suchas inducible nitric oxide synthase iNOS cyclooxygenase 2 COX2myeloperoxidase MPO and eosinophil peroxidase EPO Respiratoryburst oxidase generates superoxide O 2 via the oneelectronreduction of oxygen by NADPH with a secondary productionof hydrogen peroxide H 2 O 2 hydroxyl radical OHhypochlorous acid HOCl and other activated forms of oxygen 1In contrast RNS including nitric oxide NO are generated mainlyunder inflammatory conditions via the
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