When you mutate a Gly residue that immediately follows an
alpha-helix to an Ala residue, the...
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Chemistry
When you mutate a Gly residue that immediately follows analpha-helix to an Ala residue, the protein becomes less stable of2.0 kcal/mol. Explain the molecular basis of this result.
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The energetics of alphahelix formation are fairly well understood and the helix content of a given amino acid sequence can be calculated with reasonable accuracy from helixcoil transition theories that assign to the different residues specific
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