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  3. which of the following statement(s) about p53 are

Which of the following statement(s) about p53 are true? p53 controls both the G2/M and the...

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Biology

Which of the following statement(s) about p53 are true?

p53 controls both the G2/M and the G1 cell cyclecheckpoints

The p53 tumor suppressor protein plays a key role in theregulation of the cell cycle and cell death

All of the above

p53 is tumor promoter protein

p53 involves in the Ub mediated proteolysis pathway

The p53 gene has a wide spectrum of mutations in humantumors

None of the above

Answer & Explanation Solved by verified expert
4.4 Ratings (566 Votes)
True p53 controls both the G2M and the G1 cell cycle checkpoints Increased expression of wildtype p53 in response to DNA damage arrests cells late in the G1 stage of the cell cycle by stimulating the synthesis of inhibitors of cyclindependent kinases such as p21WAF1 When p53 is expressed at a level comparable to that induced by DNA damage in other cells most MDAH041 cells arrested in G1 but a    See Answer
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