You are reading a research study where the researchers areinvestigating osteoarthritis pain. In the study, subjects are giveneither an anti-inflammatory drug injection or a saline injection toreduce osteoarthritis joint pain. A study subject reported thatsince she received her study injection, her arthritis pain does notseem to have improved. In fact, her pain is getting worse. What isa possible reason for her continued osteoarthritis pain? Theresearch subject likely received the anti-inflammatory study drug,but it just has not yet taken effect. The research subject isresistant to anti-inflammatory agents. The research subject likelyreceived a placebo injection, such as saline. The research subjecthas an allergy to anti-inflammatory agents.