You are studying a transcriptional activator proteincalled CYK1, which activates cytokine genes in immune cells and hasboth a nuclear localization and a nuclear export signal and isnormally found both in the nucleus and in the cytosol at comparableconcentrations. CYK1 has a high-affinity binding partner in thenucleus (the binding partner is restricted to the nucleus). Uponactivation of a certain signaling pathway, the binding proteinpartner is tagged for degradation. Explain the outcome ofactivation of the signaling pathway on cytokine gene expression andthe localization of the transcriptional activator.
