Your next patient is Mr. Johnson, who also has congestive heart
failure. He is taking furosemide...
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Your next patient is Mr. Johnson, who also has congestive heartfailure. He is taking furosemide (Lasix) as part of his drugregimen. He says, “These are my water pills, the doctor tells me.They make me go and go!†Furosemide acts in the ascending limb ofthe Loop of Henle to block the NKCC transporter (ie, prevent itfrom transporting Na+, K+, and 2Cl- from the tubular fluid into thetubular epithelial cells). Why does the furosemide (Lasix®) makeMr. Johnson urinate so much?
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Furosemide Frusemide Because it is a HIGH CEILING LOOP DIURETIC Diuretics natriuretics are drugs which cause a net loss of Na and water in urine Prototype drug The development of this rapidly acting highly efficacious oral diuretic was a breakthrough Its maximal natriuretic effect is much
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