Logo
Home Study Material Contact Search
AI Chat FREE
  1. sciences
  2. biology
  3. in dna polymerases, the 3’ hydroxyl end att

In DNA polymerases, the 3’ hydroxyl end attacks the phosphorus on the incoming nucleotide triphosphate to...

60.2K

Verified Solution

Question

Biology

In DNA polymerases, the 3’ hydroxyl end attacks the phosphoruson the incoming nucleotide triphosphate to add another nucleotideto the growing chain. a) These enzymes requireMg2+. What function might this cofactor serve in theenzymatic process?    b) How doesthe mechanism explain the inability of the polymerase to synthesizeDNA using nucleotide monophosphates? c) How doesthe mechanism explain how some DNA polymerases can replace RNAprimers and damaged DNA (“nick translation,”) but not seal thebackbone (“ligation”)?

Answer & Explanation Solved by verified expert
4.1 Ratings (839 Votes)
a The catalytic mechanism of DNA polymerase involves two magnesium ions These ions are coordinated to the phosphate groups of the incoming nucleotide triphosphate and to three Asp residues The Asp residues are highly conserved and present in all DNA polymerases    See Answer
Get Answers to Unlimited Questions

Join us to gain access to millions of questions and expert answers. Enjoy exclusive benefits tailored just for you!

Membership Benefits:
  • Unlimited Question Access with detailed Answers
  • Zin AI - 3 Million Words
  • 10 Dall-E 3 Images
  • 20 Plot Generations
  • Conversation with Dialogue Memory
  • No Ads, Ever!
  • Access to Our Best AI Platform: Zin AI - Your personal assistant for all your inquiries!
Become a Member

Other questions asked by students

Q

Mogoin Gol is a Mongolian coal mining company. The expected free cash during the next three...

Finance
Q

What are two forms of blood doping that result in polycythemia, and what are the potential...

Medical Sciences
Q

An unbalanced engine mounted on an elastic support imposes a periodic vertical force on the support...

Mechanical Engineering
Q

EXERCISE Fill in the blank 1 DNA replication takes place during the 2 The enzyme...

Biology
Q

Which statement is the contrapositive of the given statement?If a person is a banjo player,...

Geometry
Q

A certain species of tree has an average life span of 130 years A researcher...

Statistics
Q

Observe that r t a cos t b sin t defines an ellipse a Find...

Calculus
Q

DIRECTIONS Use this information to answer Parts A and B Consider the following recursive formula...

Algebra
Q

Explain and provide a real life business example for equivalent units. Explain the importance ...

Accounting
Q

can you answere question 2? 1. Goff Corporation sells products for $75...

Accounting
Q

Required information [The following information applies to the questions displayed below.] Reggie...

Accounting
Q

Numerical Inc. incurred the following costs during 2022 . Work in process inventory was $1,350...

Accounting