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Integral membrane proteins have a N-terminal signal sequence, and are synthesized on ribosomes associated with...

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Biology

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Integral membrane proteins have a N-terminal signal sequence, and are synthesized on ribosomes associated with endoplasmic reticulum (ER). The synthesis of the transmembrane domain and its translocation to ER membrane is proposed to be guided by internal hydrophobic start-transfer and stop-tra nsfer sequences. Please briefly explain how the signal sequences: internal hydrophobic start-transfer and stop-transfer sequences, guide the arrangement and translocation of an integral membrane protein with two transmembrane domains (the protein passes the membrane twice) in the membrane.

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