Neuroscience
1. The net current flowing through an ion channel at a cell’s
resting potential flows in...
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Neuroscience
1. The net current flowing through an ion channel at a cell’sresting potential flows in one direction determined by theequilibrium potentials for the ions that flow through it. Giventhis, how is it possible for a hair cell in the inner ear toalternately hyperpolarize and depolarize during sound waves whenthey only have a single mechanosensitive ion channel (TMC1/TMC2heteromer)?
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Sensory transduction in auditory and vestibular hair cells requires expression of transmembrane channellike Tmc 1 and 2 genes but the function of these genes is unknown To investigate the hypothesis that TMC1 and TMC2 proteins are components of the mechanosensitive ion channels that convert mechanical information into electrical signals we recorded wholecell and singlechannel currents from mouse hair cells that expressed Tmc1 Tmc2 or mutant Tmc1 Cells that expressed Tmc2 had high calcium permeability and large singlechannel currents while cells with mutant Tmc1 had reduced calcium permeability and
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