Question 9 (4 pts)
The genetic term “loss of function†is used to describeany mutation in the DNA that leads to a particular protein thatcannot function. There are many reasons why a protein may not befunctioning any longer…digging into your knowledge on mechanism ofgene expression and gene expression regulation, describe a mutationthat could lead to a loss of function mutation. Where is themutation in the gene? What function of gene expression or geneexpression regulation is it affecting? How is it leading to a lossof function for the protein encoded for within thatgene?
But I’m going to restrict your answer…describe amechanism that DOES NOT include a point mutation leading tomissense, nonsense or frameshift – in other words, choose amutation/mechanism other than a mutation that leads to a change inthe protein coding region of a mature mRNA. I want you to thinkoutside of that particular box.
