Your project should be on temperature adaptation orthermostability of proteins.
For a temperature adaptation project select an ectothermicorganism with sub-species living in different climates. You willthen focus on one protein, preferably an enzyme, for which you needto find amino acid sequences (one for each sub-species). You alsoneed at least one crystal structure of this protein with enoughsequence similarity to your selected amino acid sequences to makeit feasible to create homology models. Finally, you will makecomparisons between the structures or homology models whilefocusing on structural features that promote protein stability.
OR
For a thermostability project select a thermophilic organism(for example a bacterium thriving in a hot spring) and one protein,preferably an enzyme for which a crystal structure is alreadyavailable. Next, you will need to search for crystal structuresand/or amino acid sequences of your selected protein in othernon-thermophilic organisms so that you can make comparisons betweenthe crystal structures (or homology models). Aim to identifystructural features that promote the thermostability of the proteinfrom the thermophilic organism.
State the parameters of your project:
Species:
Protein(s):
PDB ID:
Confirm that you will have access to protein sequences and atleast one protein structure (as a template for homology modeling)so that you can carry out your project. Post the accesscodes for the sequences and the PDB-ID(s)here:
Make a list of structural features that promote proteinstability:
Note: Except the isocitrate dehydrogenaseprotein.
example like in the below articke
